|
| Study on therapeutic mechanism of Neiyifang in treating endometriosis |
| |
| View Full Text View/Add Comment Download reader |
|
| KeyWord:endometriosis prostaglandin β-endorphin Neiyifang |
| Author Name | Affiliation | E-mail | | Yu Chao-qin | Changhai Hospital, Second Military Medical University, 200433, Shanghai | chaoqyu81 @ hotmail. com | | Cai Zai-long | Department of Biochemistry, Basic Board, Second Military Medical University, China | | | Liu Yu-huan | Changhai Hospital, Second Military Medical University, 200433, Shanghai | | | Wang Da-zeng | Longhua Hospital, Shanghai TCM University, China | | | Wang Zu-qian | Longhua Hospital, Shanghai TCM University, China | |
|
| Hits: 1026 |
| Download times: 581 |
| Abstract: |
| Objective: To observe the clinical effect of Neiyifang (NYF) in treating endometriosis and to explore its therapeutic mechanism through observing its influence on plasma β-endorphin (β-EP) in different menstrual stages and levels of prostaglandins (PGs) in menstruation.Methods:NYF was administered to 104 patients with endometriosis one dose daily with 3 successive menstrual cycles as one therapeutic course. Peripheral blood β-EP level in follicular, luteal and menstrual stages, as well as PGF2α, PGE2, thromboxane B2 and 6-keto-PGFl α levels in menstrual stage were detected by RIA, and controlled with those in 15 healthy persons.Results: (1) The total effective rate of NYF was 81.3% and it showed significant effect in improving patients’ clinical symptoms and physical signs; (2) In menstrual stage, the levels of β-EP, 6-keto-PGFα/ TXB2 were lower(P <0.05) and levels of PGF2α, PGE2, TXB2 and 6-keto-PGF1α were higher (P< 0. 05) in patients than those in control, and the higher the level of PGE2, the severer the menalgia, (3) NYF could increase levels of β-EP, 6-keto-PGF1α, and reduce levels of PGF2α, PGE2α in menstrual stage of patients (all P<0.05).Conclusion: (1) NYF has good clinical effect in treating endometriosis; (2) Patients’ symptom of menalgia is closely related with the excessive high levels of PGF2α and PGE2, PGI2/TXA2 ratio disturbance, and excessive low level of β-EP; (3) NYF could significantly decrease the PGE2, PGF1α levels, increase the 6-keto-PGF1α/TXB2 ratio and the level of β-EP, so as to alleviate the menalgia in patients with endometriosis. This item was supported by National Funds of Natural Sciences(No. 30070942) |
| Close |
|
|
|
