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| Effect of Astragalus Injection on left ventricular remodeling in aged patients with acute early-stage myocardial infarction |
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| KeyWord:myocardial infarction, the aged, left ventricular remodeling, Astragalus Injection |
| Author Name | Affiliation | E-mail | | Zhang Jin-guo | Affiliated Hospital of Jining Medical College, 272029, Shandong | jgzhang@183.ha.cn | | Gao Dong-sheng | Affiliated Hospital of Jining Medical College, 272029, Shandong | | | Yang Na | Hebei Provincial People’s Hospital, 050051, Shijiazhuang | | | Liu Li-xin | Affiliated Hospital of Jining Medical College, 272029, Shandong | | | He Hua | Affiliated Hospital of Jining Medical College, 272029, Shandong | | | Dong Hai-xin | Affiliated Hospital of Jining Medical College, 272029, Shandong | | | Liu Xue-ling | Affiliated Hospital of Jining Medical College, 272029, Shandong | | | Chen Ting | Jining Medical College, 272013, Shandong | | | Wang Xue-zhong | Hebei Provincial People’s Hospital, 050051, Shijiazhuang | | | Liu Ya-jie | Affiliated Hospital of Jining Medical College, 272029, Shandong | |
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| Abstract: |
| Objective: To observe the effect of Astragalus Injection (AI) on left ventricular remodeling in aged patients with acute myocardial infarction (AMI). Methods: Patients with AMI were randomly divided into the AI group (46 cases) treated with AI and the control group (46 cases) treated conventionally. Left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), anterior endocardial segmental length (ASL) and posterior endocardial segmental length (PSL) were all assessed by echocardiogram after 1 week and 4 weeks treatment. The cardiac systolic and diastolic functions were detected by nuclide gating cardiac blood pool imaging at the 4th week. Results: After four weeks' treatment, no obvious change of LVEDVI, LVESVI and ASL in the AI group was found, but these indexes increased significantly in the control group, with significant difference shown between the two groups (P<0. 05). As compared with the control group, the left ventricular ejection fraction (LVEF), left ventricular peak ejecting rate (LVPER) and left ventricular peak filling rate (LVPFR) were heightened, the time for peak filling rate (LVTPFR) in the left ventricle was shortened in the AI group. Conclusion: AI is one of the effective drugs in reversing left ventricular remodeling in aged patients with AMI. |
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