中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Ding Xiao-fan	Provincial Center of Radiation Oncology, Gansu Academy of Medical Sciences, 730050, Lanzhou	xiaofand@hotmail.com
Li De-xing	Provincial Center of Radiation Oncology, Gansu Academy of Medical Sciences, 730050, Lanzhou
Zhao Lin	Provincial Center of Radiation Oncology, Gansu Academy of Medical Sciences, 730050, Lanzhou

Hits: 1218

Download times: 549

Abstract:

Objective: To explore the mechanism of Qingre Buyi Decoction (QBD) in prevention and treatment of radiation enteritis in rats.Methods: Forty-eight Wistar rats were randomly divided into four groups, the TCM group, the WM group, the model group and the control group, 12 in each group. Rats in the former three groups were given orally with QBD, norfloxacin and normal saline once a day for 7 successive days, after being irradiated with X-ray at single dose of 10 Gy for modeling of radiation enteritis, while rats in the control group were untreated. Animals were sacrificed at the end of the medication. NO concentration, mean height and number of villi per centimeter in their small intestinal mucosa were measured.Results: The intestinal NO concentration was significantly lower in the TCM and WM groups than that in the model group(P<0.05), while the number of villi was significantly more and the height higher in the former two groups than those in the model group (PConclusion: QBD could inhibit the production of NO, increase the number and height of intestinal villi in rats with radiation enteritis, suggesting that it could reduce the inflammatory reaction of intestinal mucosa to irradiation, protect mucosa from radiation damage, and promote the regeneration of mucosa.