中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury

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KeyWord:electroacupuncture, ischemia/reperfusion injury, ischemic preconditioning, malondialdehyde, superoxide dismutase

Author Name	Affiliation	E-mail
Wang Xiang-rui	Renji Hospital Affiliated to Shanghai Second Medical University, 200001, Shanghai	wxrui@hotmail.com
Yu Qin-yan	Renji Hospital Affiliated to Shanghai Second Medical University, 200001, Shanghai
Yan Jun	Renji Hospital Affiliated to Shanghai Second Medical University, 200001, Shanghai
Sun Da-jin	Renji Hospital Affiliated to Shanghai Second Medical University, 200001, Shanghai

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Abstract:

Objective: To investigate the effects of electroacupuncture and ischemic preconditioning (IPC) on circulatory function in pigs with myocardial ischemia/reperfusion injury. Method: Eighteen pigs with myocardial ischemia/reperfusion injury were randomly allocated into three groups, 6 in each. Group I was the control group, group II was the group that received IPC, and group III was that received both electroacupuncture and IPC. Blood malondialdehyde (MDA), superoxide dismutase (SOD), creatine phos-phokinase (CPK) and its isoenzyme (CK-MB), coronary artery flow and myocardial heat-shock protein (HSP) mRNA expression were detected for evaluation. Results: After treatment, the MDA content was decreased and SOD activities increased significantly in the acupuncture and IPC group compared with the control group (P<0. 05 respectively). The levels of CPK, CK-MB at 20, 60 min after reperfusion were significantly higher than those before treatment, but the levels in group III and group n were remarkably lower than those in group I . HSP70 mRNA expression was found to be increased in group II and group III at 60 min after ischemia/reperfusion compared with those in group I . Conclusion: Electroacupuncture can enhance the myocardial protection of IPC against ischemia/reperfusion injury. The.protective mechanism may be related to the improvement of antioxidation and the increased expression of HSP70 gene.