中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Liu Hong-fang	Beijing University of TCM, 100029, Beijing	huchensheng@pitj.com.cn
Tong Xiao-lin	Chinese Academy of Medical Sciences, Peking Union Medical College, China
Wang Qmg-guo	Beijing University of TCM, 100029, Beijing
Zuo Ping-ping
Guo An-chen
Liu Hong-xing	Chinese Academy of Medical Sciences, Peking Union Medical College, China

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Abstract:

Objective: To investigate the effect of Kaiyu Qingwei granule (KYQWG) on the insulin binding capacity of liver and skeletal muscular cell membrane and serum insulin-like growth factor-1 (IGF-1) in streptozotocin-induced diabetic rats.Methods: Rats in four experimental groups were investigated: the control group, the model group, the KYQWG group and the Metformin group. The insulin binding rate (IBR) of liver and skeletal muscular cell membrane was detected by receptor-ligand radiometric method and changes of serum levels of glucose, insulin and IGF-1 were observed before and after 4 weeks of medication.Results: The KYQWG group had a lower blood glucose level and IBR of liver and muscular cell membrane, as compared with those in the model group (P<0.01 or P<0.05), and a higher level of IGF-1 than that in the model group(P<0.01), but had no obvious changes in the serum level of insulin.Conclusion: KYQWG may increase the serum level of IGF-1 in diabetic rats, thus to decrease the insulin resistance at ante-receptor sites and improve the sugar metabolic disturbance in rats with diabetes mellitus.