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| Clinical study of Gushen tablet in reducing children’s nephrotic syndrome relapse |
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| KeyWord:Gushen tablet children nephrotic syndrome relapse adrenocortical function T lymphocyte subpopulation |
| Author Name | Affiliation | | Yun Ying | The First Affiliated Hospital, Henan College of TCM, 450000, Zhengzhou | | Gao Ya | Henan Academy of TCM, China | | Ma Yu-hong | The First Affiliated Hospital, Henan College of TCM, 450000, Zhengzhou | | Liu Wang-le | Hospital of Henan TCM College, China | | Zhao Meng | Zhengzhou City Children Hospital, China | | Gao Zhi-ming | The First Affiliated Hospital, Henan College of TCM, 450000, Zhengzhou |
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| Abstract: |
| Objective: To explore the effect of Gushen tablet (GST) in reducing the relapse of children’s nephrotic syndrome and the possible mechanism of drugs used.Methods: Fifty children with primary nephrotic syndrome who had been induced and alleviated with regular glucocorticoid (GC) were randomly divided into two groups: the GST group used GST and standard middle-long term course of GC, and the control group adopted standard middle-long term course of GC and immunoinhibitory or immunomodulatory agents for treatment. The 0. 5, 1 and 2 years after the treatment the relapse episodes, time for urinary protein negative conversion after relapse, the episodes of patients infection and relapse after infection were evaluated. Before and after treatment the plasma cortisol and T lymphocyte subpopulation were determined.Results: The relapse rate of GST group: the rates after 0. 5, 1, 2 years were 20. 0%, 30. 0% and 40. 9%, and the frequent relapse rate were 0, 6. 7% and 9. 2% respectively, which were lower than those of control group (60. 0%, 70. 0%, 69. 2% and 25. 0%, 15. 0%, 15. 4% respectively); in the GST group no relapse occurred within 0. 5 year, the relapse rate after 1 and 2 years reduced by 40. 0% and 28. 3%, compared with those of the control group (allP < 0.05); during the observation period, the mean infection/every child patient was 1. 86 episodes in GST group, after infection the nephrotic relapse rate was 28. 3%, which was lower than that of the control group (2. 25 episodes, 71.1%,P < 0.05); the relapse per patient in GST group was 0. 8 episodes, time for urinary protein negative conversion was 12. 00± 8. 98 days, lower than those of control group (1. 6 episodes, 20. 75±11. 95 days,P < 0. 05); 3 months after GST treatment the plasma cortisol level normalized, and the CD4/CD8 ratio elevated (P < 0.05).Conclusion: GST could possibly reduce the relapse of children nephrosis, and the frequent relapse and relapse episodes, and the time for post-relaptic urinary protein negative conversion shortened, the plasma cortisol elevated, and the adjustment of cellular immunity disturbance promoted. The item was supported by the Science and Technology Department of Henan Province (No. 941200528) |
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