中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Shi Da-zhuo	Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing	shidz@public.fhnet.cn.net
Liu Jian-gang	Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing
Dong Guo-ju	Xiyuan Hospital, China Academy of Traditional Chinese Medicine, 100091, Beijing

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Abstract:

Objective: To examine the therapeutic mechanism of Yuxingeng liquid (YXGL) on early ventricular remodeling in Wistar rats with acute myocardial infarction(AMI).Methods: Measuring the cardiac index (CI), left ventricular weight (LVW) and cardiac myocyte dimension and observing the concentration of endothelin (ET) and angiotensin II (Ang II) in the plasma and myocardium. AMI models were established by ligature of left anterior descending coronary artery and the rats with AMI were randomly divided into 6 groups: the model group, sham-operation group, captopril group, high dosage YXGL group, middle dosage YXGL group and low dosage YXGL group. From the next day after modeling, the rats had been given YXGL through the gastric tube, which lasted for 4 weeks. And then, CI, LVW and concentration of ET and Ang II in the plasma and myocardium were tested.Results: Comparing with model control group, high dosage YXGL, middle dosage YXGL and captopril can all significantly reduce CI, LVW, cardiac cell dimension and content of ET and Ang II in both plasma and myocardium (P < 0.05 orP < 0.01).Conclusion: YXGL can remarkably reduce LVW, CI and concentration of ET and Ang II, and lowering the concentration of ET and Ang II is possibly one of the mechanisms intervening the pathological course of the early ventricular remodeling in rats with AMI. State Natural Science Fund (Approval No. 39870942)