中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Liang Hui	Department of Integrated TCM and Western Medicine, Huashan Hospital, Fudan University, 200040, Shanghai	wenl937@163.com
Chen Hu	Department of Integrated TCM and Western Medicine, Huashan Hospital, Fudan University, 200040, Shanghai
Gao Yin	Department of Integrated TCM and Western Medicine, Huashan Hospital, Fudan University, 200040, Shanghai
Cai Ding-fang	Department of Integrated TCM and Western Medicine, Huashan Hospital, Fudan University, 200040, Shanghai

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Abstract:

Objective: To investigate muscone's neuroprotective action and it s mechanism in rats with acute cerebral ischemic injury. Methods: Rat focal ischemic model of middle cerebral artery occlusion(MCAO) was establi shed by thread inserting method. TTC staining, RT PCR and Western blot analys is were used to study the effects of muscone on infracted volume, EAAC1mRNA and protein levels.Results: Infarcted volume in the muscone treated gr oup was significantly lower than that in the model control group. Compared with normal group, EAAC1 mRNA level increased in the model control group at 6 and 24 hrs, and protein level increased at 24 hrs after modelling, muscone could reduc e the increased expression in model rats. Conclusion: Muscone po ssesses the action of neuroprotection, its mechanism may be related to reduction of EAAC1 and protein expressions.