中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation
Dong Xiang-yu	Paediatrics Department, The Second Affiliated Hospital of Lanzhou Medical College, 730030, Lanzhou
Ni Qian	Paediatrics Department, The Second Affiliated Hospital of Lanzhou Medical College, 730030, Lanzhou
Shen Yang	Paediatrics Department, The Second Affiliated Hospital of Lanzhou Medical College, 730030, Lanzhou

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Abstract:

Objective: To observe the effect of Astragalus Injection (Al) on levels of blood selenium (Se) and cytokines, and T cellular immune function with viral myocarditis (VM) in children.Methods: Eighty children with VM were randomly divided into 2 groups. The control group consisted of 38 patients, to whom conventional therapy, including energy mixture, vitamin C and coenzyme Q₁₀, etc. were given. The treated group (n = 42), to whom combination therapy of conventional therapy and Al were given. The levels of blood Se and cytokine, including interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and also evaluation of T lymphocyte subsets and cardiac function were observed.Results: The results showed that after treatment, the levels of blood Se were significantly higher (P<0. 01), while IL-1, IL-6 and TNF-α were significantly lower (P<0.01) than those before treatment in the control group. The left ventricular end diameter (LVED) were significantly decreased (P<0.01), left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were significantly increased than those before treatment in the treated group(P<0.01, P<0.05). T lymphocyte subsets got normalized (P<0.01), and compared with the control group, the difference was significant (P<0.01).Conclusion: Astragalus membranaceus possesses anti-viral effect, adjusts the balance of cytokine and T cellular immunity, and improves the clinical manifestation and cardiac function. It is an effective approach in treating viral myocarditis.