中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Mou Kuan-hou	Xi’ an Jiaotong University, 710049, Xi’ an	mkhn@tom.com
Feng Jie	Xi’ an Jiaotong University, 710049, Xi’ an
Zhang Xian-qi	Xi’ an Jiaotong University, 710049, Xi’ an
Yu Bing	Xi’ an Jiaotong University, 710049, Xi’ an
Zhou Ai-ming	Xi’ an Jiaotong University, 710049, Xi’ an

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Abstract:

Objective: To investigate the effect of Malytea Scurfpea fruit (MSF) on adhesion and migra tion of melanocyte. Methods: Human epidermal melanocytes were treated with MSF and examined for its adhesion to bovine serum fibronectin-coated culture plate and for its migration into micropore filters, which werethen compared with those of untreated control. Results: Compared with the control, MSF treated melano cytes were easier to adhere to the dishes and move. Into the filters in a dose-dependent manner, but when the dose of MSF was higher than 150 μg/mi, the adhesion and migration could not be significantly increased. And it was noticed that when the concentrations of MSF was 10μg/ml, significant statistical difference did show between the migration of the treated and untreated melanocytes (P＜0.05) though the adhesion was not increased significantly. Conclusion: MSF had the ability to affect melanocyte adhesion and migration. This could explain, in part, the mechanism of MSF in curing vitiligo lesions.