中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Yang Zhen-jiang	Shenzhen Municipal TCM Hospital, 518033, Guangdong	dzjysz@163.com
Zhao Xia	Shenzhen Municipal TCM Hospital, 518033, Guangdong
Zou Ying-zhen	Shenzhen Municipal TCM Hospital, 518033, Guangdong
Feng Yu-li	Shenzhen Municipal TCM Hospital, 518033, Guangdong
Dai Ling	Shenzhen Municipal TCM Hospital, 518033, Guangdong

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Abstract:

Objective: To study the effect of Suiqing Pill (SQP), a TCM compound drug that can activate blood circulation and get rid of blood stasis, on angiogenesis in tumor and its possible mechanism.Method: BALB/c nude mice were inoculated with melanoma cell line B16 at right armpit subcutaneously to establish cancer spontaneous metastasis model. Levels of microvessel density (MVD), vascular endothelial growth factor (VEGF) and protein expression of matrix metalloproteinase-2 (MMP-2) in tumor tissues were observed and compared.Results: Strong expression of anti-Factor VIII (FVIII) related antigen and plentiful tumor angiogenesis were seen in model control animals, while in the high-dose and low-dose SQP treated model mice, MVD was inhibited by 33.5% and 22.6% respectively (P<0.01,P<0.05). The strong positive protein expression of VEGF and MMP-2 in model control also reduced in the SQP treated groups.Conclusion: SQP could inhibit tumor angiogenesis, protein expression of VEGF and MMP-2 in nude mice B16 melanoma models. This study was supported by Guangdong Provincial TCM Administration Bureau (No. 98107)