|
| Study of Tripterygium associated with nicotinamide in treating late-onset autoimmune diabetes mellitus in adults |
| |
| View Full Text View/Add Comment Download reader |
|
| KeyWord:late-onset autoimmune diabetes mellitus in adults Tripterygium nicotinamide |
| Author Name | Affiliation | E-mail | | Liu Jiang-hua | The First Affiliated Hospital to Nanhua University, Huna, 421001, Hengyang, China | jianghua990@sohu.com | | Duan Shi-fang | The First Affiliated Hospital to Nanhua University, Huna, 421001, Hengyang, China | | | Liu Zhi-wen | The Second Hospital of Xiangya, Zhongnan University, China | | | Liu Zong-han | Biochemistry and Bio-technology Experimental Center, Nanhua University, China | | | Cao Ren-xian | The First Affiliated Hospital to Nanhua University, Huna, 421001, Hengyang, China | | | Wen Fang | The First Affiliated Hospital to Nanhua University, Huna, 421001, Hengyang, China | | | Wen Ge-bo | The First Affiliated Hospital to Nanhua University, Huna, 421001, Hengyang, China | |
|
| Hits: 1040 |
| Download times: 525 |
| Abstract: |
| Objective: To explore the effect of Tripterygium polyglycoside (TP) associated with nicotinamide on the islet cell function, immune parameters and lipoperoxide (LPO) in adult patients with late-onset autoimmune diabetes mellitus (LADA) Methods: Thirty-six cases of LADA were randomly divided into three groups: TP group (n= 12), treated with TP plus orally taken metformin; combined treatment group (n =12), treated with TP combined with nicotinamide and metformin, and control group (n = 12) treated with metformin alone. They were followed-up for 18 months. Results: (1) Compared with the control group after 9months of treatment, postprandial plasma glucose and LPO in combined treatment group were decreased (P ＜0.05), and the postprandial C-peptide was higher (P＜0.05). At the 18th month, the value of postprandial C-peptide in the TP and combined treatment group was higher than that in the control group. The slL-2R level of both TP and combined treatment groups were lowered (P＜0.01); (2) Islet cell antibody (ICA) positive of 5 cases in the TP group and 6 cases in the combined treatment group got converted to the negative respectively, while only one in the control group at the time (P＜0.05) ; (3) The level of LPO in the combined treatment group was significantly lower than that in the TP group at the 18th month of treatment (P＜0.05).Conclusion: TP combined with nicotinamide played a role in immunity regulation, decreasing the titer of islet cell antibody and slL-2R, which also reduced the production of LPO and had a tendency to improve islet cell function in early LADA patients. |
| Close |
|
|
|
