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| Study of interference treatment by Xuesaitong soft capsule on patients of nephrosis syndrome with Qi deficiency and blood stasis during dose reducing stage of corticosteroid |
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| KeyWord:nephrosis syndrome corticosteroid qi deficiency and blood stasis Xuesaitong soft capsule |
| Author Name | Affiliation | | Lu Yong | Nephropathy Department, The First Affiliated Hospital to Anhui College of TCM, 230031, Hefei, China | | Wang Yi-ping | Nephropathy Department, The First Affiliated Hospital to Anhui College of TCM, 230031, Hefei, China | | Zhang Li | Nephropathy Department, The First Affiliated Hospital to Anhui College of TCM, 230031, Hefei, China |
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| Abstract: |
| Objective: To observe the effect of Xuesaitong (XST) soft capsule in interference treatment on patients of nephrosis syndrome (NS) during corticosteroid (CS) dose reducing stage.Methods: Seventy-one NS patients applying prednisone and initiating dose reducing stage were randomized into trial group and control group. On the basis of conventional prednisone dose reduction of both groups, the trial group was given additionally XST, and the treatment course ended with the reduction to maintenance dose. In the course of observation, those who did not comply with the criteria of observation were excluded. Before and after the dose reduction, TCM syndrome scoring, 24 hrs urinary protein amount, blood β2-microglobulin (β2-MG), urinary β2-MG, blood fibrinogen (Fbg), plasma prothrombin time (PT), blood lipid, etc. were observed.Results: The trial group of XST could obviously lower their urinary protein amount and blood lipid level (P<0.05 orP<0.01), markedly improve the blood coagulation parameters (P<0.01), improve the TCM syndrome and CS induced adverse reaction (P<0.05 orP<0.01), also obviously reduced the recurrence rate of NS (P<0.05).Conclusion: XST could obviously improve the clinical symptoms and renal impairment parameters in NS patients during CS dose reduction stage, improve the CS induced adverse reaction and prevent the recurrence of NS. |
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