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Experimental study on observation of hemorheologic parameters of hydrocortisone caused Shen-Yang deficiency in rat models
  
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KeyWord:hydrocortisone  Shen deficiency  hemorheology
Author NameAffiliationE-mail
He Lan The Third Hospital and Basic Medicine Department, Beijing University, 100083, Beijing, China lhem@163bj.com 
Mao Teng-min The Third Hospital and Basic Medicine Department, Beijing University, 100083, Beijing, China  
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Abstract:
      Objective: To explore the relationship between Shen deficiency and blood stasis. Methods:Using consecutive intramuscular injection of hydrocortisone to build Shen-yang deficiency model rats, and detect their hemorheological and biochemical parameters. Results: Comparison between the model group and control group showed that the in vitro thrombus significantly lengthened in the model group (P<0.05), the dry weight increased (P<0.01), hematocrit and whole blood viscosity under high sheared change lowered (P<0.05), blood glucose elevated (P<0.01), and RBC infiltration index, aggregation index increased (P close to 0.05). Conclusion: Under the condition of Shen-yang deficiency, although blood does not show such properties of blood stasis as being "viscous, concentrated, coagulated and aggregated", partial change of hemorheology occurs, and it is liable to form thrombus, which proves that the Shen deficiency status is accompanied with the tendency of blood stasis.
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