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| Two-year observation of the clinical efficacy in treating chronic hepatitis B patients with Ganxian recipe and lamivudine |
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| KeyWord:Ganxian recipe lamivudine chronic hepatitis B virus mutation anti-viral treatment |
| Author Name | Affiliation | E-mail | | Shen Wei-sheng | Jiangyin Hospital Affiliated to Medical College of South Eastern University, Jiangyin, 214400, Jiangsu | sws6275171@vip.sina.com | | Yang Hong-zhi | TCM Department, The Third Hospital Affiliated to Sun Yat-sen University of Medical Sciences, China | | | Hong Qi | Jiangyin City Center for Disease Prevention and Control, China | | | Zhang Yong-qiang | Jiangyin Hospital Affiliated to Medical College of South Eastern University, Jiangyin, 214400, Jiangsu | | | Xie He-ping | TCM Department, The Third Hospital Affiliated to Sun Yat-sen University of Medical Sciences, China | | | Bian Zhuang | TCM Department, The Fifth Hospital Affiliated to Sun Yat-sen University of Medical Sciences, China | |
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| Abstract: |
| Objective:To evaluate the clinical efficacy of Ganxian recipe (GXR) and lamivudine (LVD) in a two-year treatment of chronic hepatitis B (CHB).Methods: One hundred and twenty patients with CHB were randomly divided into the combinedly treated group (combined group) of 40 CHB patients who were treated with GXR combined with LVD. Another 40 CHB patients were treated with LVD alone (WM group), and still another 40 CHB patients were treated with GXR alone (TCM group). All these cases were randomly controlled and observed for two years.Results: Comprehensive efficacy: Total effective rate of the combined group (complete response and partial response) was 92.5%, while that of the WM group was 67.5% and TCM group 57.5%, respectively, with the difference between them was significant (P<0.01); after treatment, the hepatic functions (AST, ALT, SB) of the three groups were all reduced, and the reduction in the combined group was particularly significant in comparison with the WM group or TCM group,P< 0.05 orP<0.01 respectively, suggesting that the effect in the combined group was better than that in the other two groups; the rate of tyrosine-methionine-aspartate-aspartate (YMDD) virus mutation: it was 7.5% in the combined group, 40.0% in the WM group, and 5.0% in the TCM group; liver fibrosis improvement parameter: after treatment, the results in the combined group got better than those in the other two groups.Conclusion: GXR could inhibit the appearance of YMDD after long-term application of LVD, and combined use has marked synergism. |
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