中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Wei Ling	Department of Gerontology, The Fifth Hospital Affiliated to Sun Yat-sen University, Zhuhai, 519000, Guangdong Province	weiling-sky@163.com
Tan Jie	Department of Gerontology, The Fifth Hospital Affiliated to Sun Yat-sen University, Zhuhai, 519000, Guangdong Province

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Abstract:

Objective: To evaluate the efficacy of Breviscapine on essential hypertension (EH) patients complicated with micro-albuminuria of renal impairment.Methods: Seventy-six EH patients were randomly assigned to the control group and the treated group, the former was given amlodipine, captopril/uropidil and the latter was given in addition Breviscapine intravenously dripped for 2 treatment courses. The indexes of serum creatinine (Cr), blood urea nitrogen (BUN), blood and urinary β₂-microglobulin (β₂-MG), and quantitative determination of 24 hrs urinary protein were evaluated before and after treatment.Results: In the control group, compared with before treatment, the quantitative determination of 24 hrs urinary protein got reduced significantly (P<0.05), while in the treated group, both urinary β₂-MG and quantitative determination of 24 hrs urinary protein got lowered significantly (P<0.05 andP<0.01). But after treatment, compared with the control group, urinary β₂-MG and quantitative determination of 24 hrs urinary protein in the treated group were obviously reduced (P<0.05).Conclusion: Besides lowering blood pressure effectively, Breviscapine could improve the renal function significantly and reduce the urinary micro-albuminuria, hence showing promising effect on renal protection.