中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Guo Yan	Department of Pharmacology, Anhui Medical University, 230032, Hefei	guoyanzx@yahoo.com.cn
Fan Li	Department of Pharmacology, Anhui Medical University, 230032, Hefei
Dong Liu-yi	Department of Pharmacology, Anhui Medical University, 230032, Hefei
Chen Zhi-wu	Department of Pharmacology, Anhui Medical University, 230032, Hefei

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Abstract:

Objective:To study the effects of total flavone of Abelmoschl Manihot L. Medic (TFA) on the function of platelets and to explore its mechanism. Methods: Rat models of artery-veins bypassing thrombus formation were used. The platelets of rabbits were collected. Platelet aggregation was induced by collagen and intracellular calcium ion concentration ([Ca2 ]i) was assayed by Fura-2 method. Results: TFA (25, 50,100 mg/kg) significantly and dose-dependently reduced the weight of thrombus. TFA (0. 025, 0.05, 0.1 mg/mi) possessed dose-dependant inhibitory effects on rabbits' platelet aggregation induced by collagen. TFA significantly reduced the resting and CaCl2-induced increase of free intracellular calcium concentration ([Ca2 ]i) in rabbit platelet in vitro. Conclusion: TFA has an antiplatelet effect via the inhibition on the influx of Ca2 .