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| Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds |
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| KeyWord:rheumatoid arthritis collagen induced arthritis HLA-DR4 transgenic mice Yangqixue Qufengshi Recipe |
| Author Name | Affiliation | E-mail | | Li Fen | Department of Rheumatology and Clinic Immunology, TheSecond Xiangya Hospital of Central-South University, 410011, Changsha | 13973127520@hnmcc.com | | Wu Hong | Department of Rheumatology and Clinic Immunology, TheSecond Xiangya Hospital of Central-South University, 410011, Changsha | | | Deng Jun-wei | Medical Research Center, The Second Xiangya Hospital of Central-South University, China | | | Fan Song-qing | Department of Pathology, The Second Xiangya Hospital of Central-South University, China | | | Tian Jing | Department of Rheumatology and Clinic Immunology, TheSecond Xiangya Hospital of Central-South University, 410011, Changsha | | | Gao Jie-sheng | Department of Rheumatology and Clinic Immunology, TheSecond Xiangya Hospital of Central-South University, 410011, Changsha | | | Zhu Ya-hui | Human Procreate Engineering Laboratory, Xiangya College of Central-South University, China | | | Lu Guang-xiu | Human Procreate Engineering Laboratory, Xiangya College of Central-South University, China | |
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| Abstract: |
| Objective: To study the effect of Yangqixue Qufengshi Recipe (YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds.Methods: Collagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG) mice and non-transgenic (NTG) mice, which partly were raised with YQXQFS, and the onset day of CIA, the level of type II collagen (C II)-reactive antibodies and the pathological scores of CIA were assessed.Results: Under HLA-DR4 TG background (compared with NTG mice), the earlier onset day of CIA (11.22 ± 3.35 days vs 16.56 ± 4.75 days,P<0.05) and higher level of C II-reactive antibodies (0.2274 ± 0. 1390 μg/ml vs 0. 1101 ± 0.0560 μg/ml,P<0.05) were observed, but the pathological scores of CIA remained unchange. YQXQFS could not influence the onset day of CIA and the level of CII -reactive antibodies, but had a certain effect on the total pathological scores (6.56 ± 3.43 scores vs 11.11 ± 5.64 scores) and bone erosion (0.22 ± 0.44 scores vs 1.67 ± 1.50 scores) of CIA on NTG mice (P<0.05), NTG YQXQFS group compared with NTG experimental group.Conclusion: YQXQFS had a certain effect on RA model, but had no significant effect on HLA-DR4 related CIA. |
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