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| Improvement of quality of life with Shenfu injection in non small cell lung cancer patients treated with gemcitabine plus cisplatin regimen |
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| KeyWord:Shenfu injection non small cell lung cancer gemcitabine cisplatin quality of life |
| Author Name | Affiliation | E-mail | | Wu Wan-yin | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | wwanyin@126.com | | Long Shun-qin | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | | | Zhang Hai-bo | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | | | Chai Xiao-shu | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | | | Deng Hong | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | | | Xue Xiao-guang | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | | | Wang Bin | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | | | Luo Hai-ying | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | | | Liu Wei-sheng | Department of Cancer, Guangdong Provincial Traditional Chinese Medicine Hospital, 510370, Guangzhou | |
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| Abstract: |
| Objective: To observe the effect of Shenfu injection (SFI) in treating non small cell lung cancer (NSCLC) patients on quality of life with gemcitabine (GEM) plus cisplatin (GP) regimen.Methods: Thirty-four patients were ready to receive GP regimen chemotherapy for treating NSCLC disease, according to lot-drawing, they were divided into SFI pre-treatment group (18 cases) and SFI post-treatment group (16 cases). SFI pre-treatment group: During the first treatment course, chemotherapy was begun with SFI 60 ml, intravenous dripping on the 3rd day, once daily, consecutively for 10 days; on the 1st day, GP regimen (GEM 1250 mg/m2, intravenous dripping, on the 1st and 8th day; cisplatin 70 mg/m2 on the 2nd day; 21 days as one cycle) was carried out; in the second treatment course GP regimen was merely given to serve as the self-control. SFI post-treatment group: the medicament sequence order was reversed from that of pre-treatment group. Using dual international quality of life (QOL) scores, the effect of SFI on the patients’ QOL was observed through randomized self preand postcrossover control.Results: The QOL in the 34 patients after being treated by SFI in combination with GP chemotherapy regimen in one group, and GP chemotherapy regimen alone in the other, was improved in different degrees, with significant difference (P< 0.01); comparision of SFI combined with GP chemotherapy regimen with GP chemotherapy alone showed that QOL in patients was significantly different (P<0.01).Conclusion: SFI could improve QOL in patients with NSCLC who were treated with GP regimen. Supported by the “999” Shenfu Injection Foundation sponsored by China National Health Ministry and Canadian Terry Fox Foundation for Cancer Research |
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