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| Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer |
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| KeyWord:Wuye Decoction non-small cell lung cancer chemotherapy lymphocyte phenotype |
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| Abstract: |
| Objective: To investigate the effect of Chinese recipe, Wuye Decoction (WYD), on immune function in patients with non-small cell lung cancer (NSCLC).Methods: Eighty-two patients of NSCLC with pathologically confirmed diagnosis, who had received operative treatment and completed the post-operational chemotherapy, were randomly assigned into 2 groups. Group A (42 cases) received WYD and Group B (40 cases) received no specific medicine. Positive rate of various peripheral lymphocyte subsets, including CD3, CD4, CD8, CD16, CD19 and CD25, in both groups was observed immediately after chemotherapy (T0) and 3 months later (T1), the same indexes of 20 healthy volunteers allocated in Group C were also determined at T0 for control.Results: The positive rates of CD4, CD4/CD8, CD16, CD19 and CD25 were significantly lower (P< 0.05) while that of CD8 was significantly higher (P< 0. 05) in Group A and B at T0 than those in Group C; at T1, these indexes, except CD25, got significantly restored in Group A with the level approaching normal range (P> 0.05), and showed significant difference from those in Group B (P< 0. 05), since these indexes in that group remained unchanged at the corresponding period. As for CD25, it was insignificantly changed in Group A after WYD treatment, and thus, at T1, it was still lower than that in Group C (P< 0.05) and showed insignificant difference as compared with that in Group B (P>0.05). Comparison of CD3 among the 3 groups showed no significant difference (P> 0.05).Conclusion: WYD could activate the immune function of NSCLC patients, and so it is recommended to be used in the treatment of NSCLC in clinical practice. |
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