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| Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a |
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| KeyWord:Shengxuening cyclosporin A aplastic anemia |
| Author Name | Affiliation | E-mail | | Zhang Xue-zhong | Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing | xuezhong1968@sina.com | | Xu Yan-li | Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing | | | Jin Juan | Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing | | | Zhang Xiu-qun | Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing | | | Zhang Lei | Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing | | | Su Ai-ling | Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing | |
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| Abstract: |
| Objective: To explore the therapy to further elevate the efficacy of the treatment of chronic aplastic anemia (CAA).Methods: Forty-five patients with CCA were assigned into two groups, the 26 patients in the treated group were treated by Shengxuening (a Chinese herbal preparation) and cyclosporin A (CsA), and the 19 patients in the control group were treated with androgen alone, with the therapeutic course lasting for over 3 months. Changes of peripheral blood picture, and the colony productivity of burst forming unit-erythroid (BFU-E), colony forming unit-erythroid (CFU-E) and colony forming unit-granulocyte macrophage (CFU-GM) in bone marrow were observed before and after 3 months treatment. The amount of erythrocyte and platelet infusion, frequency of infection, condition of hemorrhage and relevant death were also observed. The follow-up study was conducted for over half a year.Results: The total effective rate in the treated group was 84.6%, which was significantly higher than that in the control group (52.6 %,P< 0.05). Levels of hemoglobin, reticulocyte, neutrophil and platelet increased after treatment in the treated group, as compared with those before treatment, with significant difference (P< 0.05), and the colony productivity of BFU-E, CFU-E and CFU-GM in bone marrow also got significantly increased (P< 0.01), and showed significant difference from those in the control group (P< 0.05).Conclusion: Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA. |
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