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| Effect of Kangxin Capsule (康欣胶囊) on the expression of nerve growth factors in parietal lobe of cortex and hippocampus CA1 area of vascular dementia model rats |
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| KeyWord:Kangxin Capsule, vascular dementia, nerve growth factor, nerve synapse, ultrastructure |
| Author Name | Affiliation | E-mail | | Dr. Jing Cai | Institute of Geriatrics, Fujian College of Traditional Chinese Medicine, Fuzhou, 350003, China | caij1@163.com | | Jian Du | Institute of Geriatrics, Fujian College of Traditional Chinese Medicine, Fuzhou, 350003, China | | | Zhen-hua Ge | Fujian Institute of Traditional Chinese Medicine, China | | | Fan Zhou | Fujian Institute of Traditional Chinese Medicine, China | | | Lin-yin Zhou | Department of Electron Microscope, Fujian Medical University, China | | | Lian-yun Chen | Department of Electron Microscope, Fujian Medical University, China | |
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| Abstract: |
| Objective To observe the effect of Kangxin Capsule (康欣胶囊, KXC) on the expression of nerve growth factor (NGF) as well as the morphology and amount of nerve synapse in the cortical parietal lobe and hippocampus CA1 area of vascular dementia (VD) model rats. Methods The model rats of VD made by photochemical reaction technique were randomly divided into five groups: the model group (MG), the high-dose, middle-dose and low-dose KXC groups (HDG, MDG and LDG), and the Western medicine hydergin control group (WMG). They were treated respectively with distilled water, high, middle and low dosage of KXC suspended liquid, and hydergin for a month. Besides, a blank group consisting of normal (non-model) rats was set up for control (CG). The ultrastructure of nerve synapse in the cortical partietal lobe and hippocampus CA1 area of the rats were observed and its density estimated. The condition of NGF positive neurons in the above-mentioned two regions were also observed by immunohistochemical stain. Results All the KXC or hydergin treated groups demonstrated a normal amount of nerve synapse with integral structure in the cortical parietal lobe and hippocampus CA1 area, which approached that in the CG and was superior to that in the MG. Also, the NGF positive neuron in all the treated groups was much more than that in MG with significant difference (P<0.01), approaching to that in the CG. Conclusion KXC could elevate the expression of NGF in the cortical parietal lobe and hippocampus CA1 area, preserve the number and morphology of synapse, thus to protect the function of nerve system from ischemic injury. Key Project supported by Health Bureau of Fujian Province (2002-101), Fujian Innovation Project for Young Scientific Talents (2002J055), Fujian Education Committee (JA02237). |
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