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Multi-centered clinical study on effects of nano-Amomi Paste in treating children’s anorexia
  
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KeyWord:nano-liposome  amoni volatile oil  paste
Author NameAffiliationE-mail
Prof. Min Wu Department of Traditional Chinese Medicine, Affiliated Xinhua Hospital of Medical College of Shanghai Jiaotong University, Shanghai, 200092, China minwu@eastday.com 
Zhan Li Department of Traditional Chinese Medicine, Central Hospital of Jing’an District, Shanghai, China  
Jian-er Yu Shanghai Municipal Hospital of Traditional Chinese Medicine, China  
Wei-wei Lu Department of Traditional Chinese Medicine, Affiliated Xinhua Hospital of Medical College of Shanghai Jiaotong University, Shanghai, 200092, China  
Ju-xiu Ni Department of Traditional Chinese Medicine, Central Hospital of Jing’an District, Shanghai, China  
Yi-lin Xia Shanghai Municipal Hospital of Traditional Chinese Medicine, China  
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Abstract:
      Objective To assess the effect and safety of nano-Amoni Paste (nmAP) in the treatment of children’s anorexia (AR). Methods One hundred and eighty patients of AR were assigned according to the randomized, double-blinded, double-simulated and parallel controlled principle to three groups, the treated group (TG), the positive control group (PCG) and the negative control group (NCG), 60 in each group. The patients in TG were treated by sticking 1.5 ml of nmAP on the acupoint of Shenque (Ren 8) once a day and orally taking placebo liquid 10 ml twice a day; those in PCG and NCG treated with sticking paste of placebo on Ren 8, and oral taking of Shanmai Jianpi Oral Liquid (山麦健脾口服液) and placebo liquid respectively, 10 ml each time twice per day. The course of treatment for all was 10 days, all patients were treated for 2 courses. Results The total effective rate and the effective rate on cardinal symptom in TG was 85.0% and 95.0% respectively, that in PCG 86.2% and 96.55% and in NCG 45.5% and 65.45%, respectively, showing significant difference between groups (P<0.05). Comparison of the clinical manifestation before and after treatment showed significant improvement in volume of food intake, appetite, complexion and reduction of restlessness symptom (P<0.05) in all three groups, and there was no adverse reaction found in them. Conclusion nmAP is an effective and safe remedy for treatment of Children’s anorexia. Supported by Nano Special Project of Science and Technology Commission of Shanghai Municipality (No.0249nm066)
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