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| Effects of Corocalm (Shuguan Capsule, 疏冠胶囊) on acute myocardial ischemia in anesthetized dogs |
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| KeyWord:Corocalm (Shuguan Capsule),acute myocardial ischemia,coronary blood flow,endothelin,mongrel dog |
| Author Name | Affiliation | E-mail | | Jian-xun Liu | Fundamental Medical Sciences Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | liujx0324@sina.com | | Xin-zhi Li | Fundamental Medical Sciences Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Wei-hong Cong | Fundamental Medical Sciences Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Jian-hua Fu | Fundamental Medical Sciences Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Xiao-hong Shang | Fundamental Medical Sciences Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | |
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| Abstract: |
| Objective To investigate the effects of Corocalm (Shuguan Capsule, 疏冠胶囊) on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism. Methods The acute ischemia model was established by ligating the left anterior descending (LAD) artery. Twenty-five dogs were randomly divided into 5 groups (5 dogs in each group): the control group (treated with normal saline 3 mL/kg), the refi ned Guanxin Capsule group (精制冠心胶囊, GXC 200 mg/kg), high and low dose Corocalm groups (48.5 mg/kg for low dose group and 194.0 mg/kg for high dose group) and the Diltiazem group (5 mg/kg). The animals were treated via a single duodenal administration after the model was established. The experiments used epicardial electrocardiogram (EECG) to measure the scope and degree of myocardial ischemia. Simultaneously, the coronary blood fl ow (CBF) and serum activity levels of creatine phosphokinase (CK) and lactate dehydrogenase (LDH) were measured by electromagnetic fl ow meter and automatic biochemical analyzer respectively. The plasma endothelin (ET) content was quantified by radioimmunoassay. Results Corocalm (48.5 mg/kg and 194.0 mg/kg) signifi cantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction. Conclusion Corocalm could improve the state of acute myocardial ischemia and infarction in dogs. The mechanism of action might be correlated to increasing CBF, inhibiting CK and LDH activities and preventing ET release. Supported by the National Key Technology Program Foundation during the 9th Five-Year Plan Period (No. 96-903-01-02) |
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