|
| Effect of Shugan Jianpi Granule () on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type |
| |
| View Full Text View/Add Comment Download reader |
|
| KeyWord:Shugan Jianpi Granule irritable bowel syndrome serotonin |
| Author Name | Affiliation | E-mail | | Zai-jian Wang | Department of Digestive Medicine, the Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100029, China | solong25@163.com | | Hui-xia Li | Department of Digestive Medicine, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100078, China | | | Jing-hua Wang | Department of Digestive Medicine, the Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100029, China | | | Fan Zhang | Department of Digestive Medicine, the Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100029, China | |
|
| Hits: 1140 |
| Download times: 486 |
| Abstract: |
| OBJECTIVE: To evaluate the effect of Shugan Jianpi Granule (, SJG) on the number of gut mucosal serotonin-positive cells (5-HT+C) in patients with irritable bowel syndrome (IBS) of stagnated Gan-qi attacking Pi (SGAP) syndrome type. METHODS: Twenty-four patients were randomized equally into three groups. All were treated with the basic conventional treatment by cognition-behavior therapy with assistance of lactein 3 tablets thrice a day. Additionally, 24 g of SJG was given three times a day to group A, and the same dosage of SJG and Smecta 15 g thrice a day was given to group B, while no additional treatment was given to the control group. The number of 5-HT+C was measured respectively before and two weeks after treatment by immunohistochemical method. RESULTS: The number of 5-HT+C decreased after treatment in all the three groups (P<0.05), but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01, respectively), while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05). CONCLUSION: SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type, and its effect is enhanced when used in combination with Smecta. |
| Close |
|
|
|
