中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Shu-wen Shen	Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
Ya Yuwen	China Academy of Chinese Medical Sciences, Beijing, 100700, China	yuwen_ya@163.com
Zhen-lu Zhang	Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
Sheng Dong	Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
Jun-tian Liu	Department of Pharmacology, Medical College, Xi’an Jiaotong University, Xi’an, 710061, China
Xiao-mei Wang	Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

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Abstract:

OBJECTIVE: To study the effect of Jinguo Weikang Capsule [see text] on the gene expression of H-ras, epidermal growth factor receptor (EGFR), P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions, and to investigate the action mechanism of JWC on gastric precancerous lesions. METHODS: A rat model with paratypical proliferation of the gastric epithelium mucosa was established by using 60Co irradiation. Rats were divided into the normal group, model group, high-, medium-, low-dose JWC treatment groups, and the vitacoenzyme control group, and were treated for 30 days. The expression of H-ras, EGFR, P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical methods. RESULTS: The expression and over-expression rates of H-ras, EGFR, P53 and C-myc gene in the high-and medium-dose JWC treatment groups were significantly lower (P<0.05) as compared with those of the model group. CONCLUSION: JWC can inhibit the expression of the H-ras, EGFR, P53 and C-myc genes expression of the gastric mucosa in rats, which may be one of mechanisms involved in suppressing or reversing gastric carcinogenesis.