|
| Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方) |
| |
| View Full Text View/Add Comment Download reader |
|
| KeyWord:tic disorder Chinese medicine Qufeng Zhidong Recipe haloperidol multicenter study |
| Author Name | Affiliation | E-mail | | Min Wu | Xinhua Hospital Affiliated to Medical School of Shanghai Jiaotong University, Shanghai, 200092, China | xinhuayiyuan123@126.com | | Guang-hua Xiao | Medical School of Shanghai Jiaotong University, Shanghai, 200025, China | | | Min Yao | Yueyang Hospital of Integrative Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China | | | Jian-ming Zhang | Xinhua Hospital Affiliated to Medical School of Shanghai Jiaotong University, Shanghai, 200092, China | | | Xin Zhang | Xinhua Hospital Affiliated to Medical School of Shanghai Jiaotong University, Shanghai, 200092, China | | | Ya-bing Zhou | Xinhua Hospital Affiliated to Medical School of Shanghai Jiaotong University, Shanghai, 200092, China | | | Jing-yan Zhang | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China | | | Shu-xia Wang | Medical School of Shanghai Jiaotong University, Shanghai, 200025, China | | | Bo Ma | Medical School of Shanghai Jiaotong University, Shanghai, 200025, China | | | Yan-ping Chen | Yueyang Hospital of Integrative Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China | |
|
| Hits: 1363 |
| Download times: 471 |
| Abstract: |
| Objective To assess the effect and adverse reaction of Qufeng Zhidong Recipe (祛风止动方, QZR) in treating children’s tic disorder (TD). Methods With multicenter randomized parallel open-controlled method adopted, the patients enrolled were assigned to two groups, 41 cases in the Chinese medicine (CM) group and 40 in the Western medicine (WM) group. They were treated by QZR and haloperidol plus trihexyphenidyl respectively for 12 weeks as one course. In total, two courses of treatment were given. The curative effect and adverse reactions were evaluated by scoring with Yale Global Tic Severity Scale (YGTSS), Traditional Chinese Medicine Syndrome Scale (TCMSS), and Treatment Emergent Symptom Scale (TESS), as well as results of laboratory examinations. Results After one course of treatment, the markedly effective rate in the CM and the WM group was 14.6% and 17.5%, respectively, and the total effective rate 43.9% and 47.5%, respectively, which showed insignificant difference between groups (P>0.05). However, after two courses of treatment, markedly effective rate in them was 73.2% and 7.5%, and the total effective rate was 100.0% and 57.5%, both showing significant differences between groups (P<0.05). Besides, the adverse reactions occurred in the CM group was less than that in the WM group obviously. Conclusion QZR has definite curative effect with no apparent adverse reaction in treating TD, and it can obviously improve the symptoms and signs and upgrade the quality of life and learning capacities in such patients. Supported by Funds from Shanghai Bureau of Health (No. 2006L014); Developing Center of Shanghai Shenkang Hospital (No. SHDC12007409); and Second Group of Construction Projects of Traditional Chinese Medicine Clinical Predominant Item (No. 2008YSZK003) |
| Close |
|
|
|
