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| Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula |
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| KeyWord:Qiyu oil gauze anal fistula wound healing vascular endothelial growth factor basic fibroblast growth factor epidermal growth factor number of blood capillary |
| Author Name | Affiliation | E-mail | | Shao-tang Li | Fujian Medical University, Fuzhou, 350004, China | lishaotang163@163.com | | Bo Cao | Department of Anorectal Diseases, the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang, 550001, China | | | Wen-Ling Deng | Department of Anorectal Diseases, the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang, 550001, China | | | Zhi Li | Department of Anorectal Diseases, the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang, 550001, China | |
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| Abstract: |
| Objective To observe the effects of the external application of Qiyu oil (芪榆油) gauze (QYOG) for promoting post-operational healing in patients with anal fistula and to explore its mechanism of action so as to provide a beneficial scientific basis for its wide use. Methods Sixty patients with anal fistula scheduled to receive simple low anal fistulectomy were equally assigned, according to the sequence of hospitalization, to the tested group and the control group, and their wounds were classified according to longitudinal diameter into three grades (Grade I with a diameter below 2 cm; Grade II, 2–5 cm; and Grade III, over 5 cm). After the operation was completed and the operational wound was sterilized with benzalkonium bromide, the wound substratum was packed with QYOG in the test group and with vaseline gauze in the control group. The packing gauze was changed every day till the wound was healed. The healing time of the patients was observed, and the number of capillaries and positive cell percentages of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and epidermal growth factor (EGF) in wound granulation tissues were counted on the 5th day after the operation. Results The wound healing time was 17.80±5.46 days in the test group, which was significantly shorter than that in the control group (21.90±6.32 days, P<0.01). The number of capillaries and positive cell percentages of VEGF and bFGF in wound granulation tissues on the 5th day in the tested group were higher than those in the control group (P<0.01), though the difference in EGF between the two groups was insignificant (P>0.05). Conclusion QYOG could shorten the wound healing time after anal fistulectomy, which suggests that it participates in the stimulation of wound granulation tissues to produce VEGF and bFGF, and thus promotes capillary genesis and improves blood circulation in wounds so as to promote wound healing. Supported by the Funds of Guiyang College of Traditional Chinese Medicine (No. 200607) |
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