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| Differences in effects of Zuojin Pills (左金丸) and its similar formulas on Wei cold model in rats |
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| KeyWord:Zuojin Pills similar formula rat Wei cold syndrome |
| Author Name | Affiliation | E-mail | | Yan-ling Zhao | Institute of Traditional Chinese Material Medica, the 302 Hospital of PLA, Beijing, 100039, China | | | Wen-li Shi | Department of Integrated Traditional and Western Medicine, the 302 Hospital of PLA, Beijing, 100039, China | | | Li-mei Shan | Institute of Traditional Chinese Material Medica, the 302 Hospital of PLA, Beijing, 100039, China | | | Jia-bo Wang | Institute of Traditional Chinese Material Medica, the 302 Hospital of PLA, Beijing, 100039, China | | | Hai-ping Zhao | Institute of Traditional Chinese Material Medica, the 302 Hospital of PLA, Beijing, 100039, China | | | Xiao-he Xiao | Institute of Traditional Chinese Material Medica, the 302 Hospital of PLA, Beijing, 100039, China | pharmacy302@126.com |
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| Abstract: |
| Objective To explore the effects of Zuojin Pills (左金丸) and its similar formulas on the stomach cold syndrome in a Wei cold model in rats. Methods The rat Wei cold model was established by intragastric administration of glacial NaOH, and the gastric mucosa injury indices, together with the levels of motilin and gastrin in the stomach, were determined. The preventive and curative effects of Zuojin Pills and its similar formulas on gastric mucosa injury were investigated. Results Zuojin Pills and its similar formulas could protect the gastric mucosa in the gastric cold model in rats at different levels. Fanzuojin Pills (反左金丸) had the best effect in inhibiting gastric mucosa injury. Conclusion The different pharmacological effects of Zuojin Pills and its similar formulas in the rat gastric cold model were partially correlated with the degrees in cold and heat properties of the formulas. Supported by National Basic Research Program of China (No. 2007CB512607), National Nature Science Foundation of China (No. 30772740) |
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