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| Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial |
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| Author Name | Affiliation | E-mail | | Xiang-xia Luo | Department of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China | | | Jun-guo Duan | Department of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China | duanjg@vip.sina.com | | Pin-zheng Liao | Department of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China | | | Lie Wu | Guang’ anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China | | | Yang-gui Yu | The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405, China | | | Bo Qiu | Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, 510220, China | | | Yu-liang Wang | Jiangsu Hospital of Traditional Chinese Medicine, Nanjing, 210029, China | | | Yu-min Li | The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, 310003, China | | | Zheng-qin Yin | Southwest Hospital, Chongqing, 400038, China | | | Xiao-ling Liu | Hospital of Optometry and Ophthalmology, Wenzhou Medical College, Zhejiang Province, 325027, China | | | Ke Yao | The Second Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, 310009, China | |
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| Abstract: |
Objective To objectively assess the effect of Qiming Granule (芪明颗粒) in the treatment of diabetic retinopathy (DR) by fluorescence fundus angiography (FFA). Methods In a multi-center, randomized, parallel controlled clinical trial, patients with DR were randomly assigned to the control group (calcium dobesilate capsule) and the test group (Qiming Granule). Changes in the retinal blood circulation time were recorded by FFA after 3 months of medication. Results Significant reduction was observed in the retinal arterio-venous circulation time (AVCT) in both groups (P<0.01), the value was 7.635±3.149 s before treatment and 5.165 ±3.382 s after treatment in the treated group, and 7.737±3.413 s and 5.313±3.472 s in the control group respectively. Qiming Granule also reduced the arm-to-retinal circulation time (ARCT, P<0.05). The value was 17.867±3.872 s before treatment and 15.643±4.648 s after treatment in the treated group, and 17.217±3.833 s and 16.312±3.613 s in the control group (P>0.05) respectively. The ARCT in the tested group was reduced, with a statistically significant difference post-medication (P<0.01). Conclusion As a Chinese medicine complex prescription, Qiming Granule may alleviate retinal hypoxia and ischemia by increasing retinal blood flow and improving the blood circulation. |
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