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Gene expression profiling of the proliferative effect of periplocin on mouse cardiac microvascular endothelial cells
  
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KeyWord:periplocin  cardiac microvascular endothelial cells  proliferation  protein serine/threonine kinase  GTP-binding  
Author NameAffiliationE-mail
Xiao-ying Wang Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China

Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China 
 
Xiu-mei Gao Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China

Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China 
gaoxiumei@tjutcm.edu.cn 
Hong Liu Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China

Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China 
 
Han Zhang Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China

Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China 
 
Yang Liu Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China

Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China 
 
Min Jiang Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China

Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China 
 
Li-min Hu Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China

Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China 
 
Bo-li Zhang Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China

Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China 
 
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Abstract:
      Objective:Periplocin is an active digitalis-like component from Cortex Periplocae,which has been widely used in the treatment of heart diseases in China for many years.According to the recommendations on the cardiovascular effect of periplocin from in vivo experiments,subsequent in vitro experiments are greatly needed for the global assessment of periplocin.The objective of this study is to investigate the cell proliferation effect and the mechanism of periplocin on endothelial cells.Methods:The proliferati...
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