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Gene expression profiling of the proliferative effect of periplocin on mouse cardiac microvascular endothelial cells |
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KeyWord:periplocin cardiac microvascular endothelial cells proliferation protein serine/threonine kinase GTP-binding |
Author Name | Affiliation | E-mail | Xiao-ying Wang | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China
Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China | | Xiu-mei Gao | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China
Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China | gaoxiumei@tjutcm.edu.cn | Hong Liu | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China
Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China | | Han Zhang | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China
Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China | | Yang Liu | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China
Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China | | Min Jiang | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China
Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China | | Li-min Hu | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China
Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China | | Bo-li Zhang | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China
Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, 300193, China | |
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Abstract: |
Objective:Periplocin is an active digitalis-like component from Cortex Periplocae,which has been widely used in the treatment of heart diseases in China for many years.According to the recommendations on the cardiovascular effect of periplocin from in vivo experiments,subsequent in vitro experiments are greatly needed for the global assessment of periplocin.The objective of this study is to investigate the cell proliferation effect and the mechanism of periplocin on endothelial cells.Methods:The proliferati... |
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