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| Effect of traditional and integrative regimens on quality of life and early renal impairment in elderly patients with isolated systolic hypertension |
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| Author Name | Affiliation | E-mail | | Hao Li | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | xyhplihao@vip.sohu.com | | Long-tao Liu | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Wen-ming Zhao | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Jian-gang Liu | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Ming-jiang Yao | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Yong-xiang Han | Traditional Chinese Medicine Hospital of Yanqing County, Beijing, 102100, China | | | Yan-peng Shen | Traditional Chinese Medicine Hospital of Yanqing County, Beijing, 102100, China | | | Xing-dong Liu | Community Health Service Centers of Yanqing County, Beijing, 102100, China | | | Li Liu | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Xue-mei Wang | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Lin-lin Cai | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | | | Jie Guan | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China | |
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| Abstract: |
Objective To observe the effect of Chinese medical regimen and integrative medical regimen on quality of life and early renal impairment in elderly patients with isolated systolic hypertension (EISH). Methods A multi-center, randomized, double-blinded controlled trail was adopted. A total of 270 cases of EISH were randomly divided into 3 groups: Chinese medicine group (CM), combination group and Western medicine group (WM). The course of treatment was 4 weeks. The clinical blood pressure, integral of quality of life (SF-36 scale), immunoglubin G (IgG), microalbumin (mALB), β2-microglobulin (β2-MG), transferrin (TRF) and N-acetyl-β′-D-glucosa-minidase (NAG) in urine were determined before and after the treatment. Results After treatment, systolic blood pressure depressed significantly in each group (P<0.05), and the combination group was superior to CM or WM group in depressing SBP (P<0.05); in each group, integral of quality of life improved in different degree, and combination group was superior to WM group in all 8 dimensions (P<0.05). The level of mALB and β2-MG in urine decreased in all groups (P<0.05), and the combination group was superior to CM group or WM group in decreasing mALB (P<0.05). Conclusions Chinese medical regimen has affirmative effect in treating EISH patients, and could lower the systolic blood pressure, improve quality of life and early renal impairment of the patients, and integrative medical regimen has superiority on account of cooperation, and deserves further study. |
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