中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Jian-yong Chen	Department of Digestive Diseases, Zhejiang Integrated Medical Hospital, Hangzhou, 310003, China	chenjy@medmail.com.cn
Feng Pan	Department of Digestive Diseases, Zhejiang Integrated Medical Hospital, Hangzhou, 310003, China
Tao Zhang	Institute of Pi-Wei, Guangzhou Traditional Chinese Medical University, Guangzhou, 510405, China
Jin Xia	Department of Digestive Diseases, Zhejiang Integrated Medical Hospital, Hangzhou, 310003, China
Yan-juan Li	Department of Digestive Diseases, Zhejiang Integrated Medical Hospital, Hangzhou, 310003, China

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Abstract:

Objective

To explore the significance of colonic epithelial cell apoptosis and tumor necrosis factor α (TNF-α) changing in pathogenesis of melanosis coli (MC) in guinea pig and the molecular mechanism of rhubarb (Rhu) in inducing the disease, by means of using different dosages of Rhu to induce the disease.