中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Effect of early intervention with extract of Huannao Yicong Decoction (还脑益聪方) on the pathologic picture of hippocampus and neurocyte apoptosis in APP transgenic mice model of dementia

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Author Name	Affiliation	E-mail
Hao Li	Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China	xyhplihao@vip.sohu.com
Lin-lin Cai	Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China
Jian-gang Liu	Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China
Long-tao Liu	Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China
Jie Guan	Endocrinal Department of Haici Medical Group, Qingdao, Shandong Province, 266033, China
Ming-fang Liu	Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China
Jia Hu	National Key Laboratory for Available Utilization of Chemical Engineering Resource, Beijing Chemical Engineering University, Beijing, 100029, China
Yun Wei	National Key Laboratory for Available Utilization of Chemical Engineering Resource, Beijing Chemical Engineering University, Beijing, 100029, China

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Abstract:

Objective

To observe the effect of early intervention using extract of Huannao Yicong Decoction (还脑益聪方, HYD) on the pathological picture of hippocampus, neurocyte apoptosis, and associated regulatory genes in β-amyloid precursor protein (APP) transgenic mice model of dementia.