中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Xiao-lin Shi	Department of Orthopaedics, Second Hospital Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, 310005, China	xlshi-2002@163.com
Kang Liu	Department of Orthopaedics, Second Hospital Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, 310005, China
Lian-guo Wu	Department of Orthopaedics, Second Hospital Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, 310005, China

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Abstract:

Osteoporosis, the sixth most common disease in the world, is bringing increasingly serious harm to people’s health. Cathepsin K, which plays an important role in bone resorption, is a potential target in the treatment of osteoporosis. Total flavonoids, the active ingredients in Rhizoma Drynariae, have shown obvious, therapeutic effect on osteoporosis. In previous studies, it was presumed that the mechanism for the therapeutic effect was through inhibiting the expression of Cathepsin K. However, there are still no detailed reports on some key issues such as the specific inhibitory results of total flavonoids on Cathepsin K and the pathway of inhibition and so on. Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.