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| Combined common femoral artery endarterectomy with superficial femoral artery stenting plus Shuxuening Injection (舒血宁注射液) infusion for chronic lower extremity ischemia: 3-year results |
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| KeyWord:chronic lower extremity ischemia endarterectomy stenting angioplasty Shuxuening Injection hybrid technique |
| Author Name | Affiliation | E-mail | | Hai Feng | Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China | | | Xue-ming Chen | Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China | | | Chen-yu Li | Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China | | | Ren-ming Zhu | Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China | | | Jie Fang | Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China | | | Tian-you Wang | Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China | Fenghai543@126.com |
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| Abstract: |
Objective To investigate the efficacy and safety of combined common femoral artery (CFA) endarterectomy with superficial femoral artery (SFA) stenting plus Shuxuening Injection (舒血宁注射液) infusion in patients with complex multifocal arterial steno-obstructive lesions of the lower extremities. Methods From March 2006 to March 2011, 104 lower limbs in 96 patients with multilevel peripheral arterial steno-occlusive disease, involving SFA as well as CFA and deep femoral artery (DFA) orifice, were treated by combined surgical with endovascular therapy, such as SFA stenting as an adjunct to CFA endarterectomy and patch angioplasty with the great saphenous vein. Before the end of the operation, 20 mL of Shuxuening Injection was infused through the catheter located in the treated artery. Technical and hemodynamic success, as well as primary and primary-assisted patency, was determined according to the Society for Vascular Surgery Guidelines. During follow-up, clinical status assessment, ankle-brachial index (ABI) test, and duplex Doppler ultrasound were administered every 6 months, and computed tomography angiography or magnetic resonance angiography was performed at 12, 24, and 36 months after discharge. Results All patients underwent successful combined CFA endarterectomy with SFA stenting treatment. The average ABI after the combination treatment increased from pretreatment of 0.32±0.21 to 0.82±0.24 (P<0.01). No perioperative death and major limb amputations occurred. The mean duration of follow-up for 104 limbs from 96 patients was 1,180 days (range, 196–2,064 days). During follow-up, 5 patients died due to myocardial infarction, cerebral infarction, or pneumonia, and 5 patients were lost to follow-up. There were 21 cases (21.4%) of restenosis, with 15 that occurred in-stent and 6 near the distal end of the stent. A total of 18 (18.3%) reinterventions were performed, including 6 balloon angioplasty, 8 restenting procedures, 2 bypass surgeries, and 2 major limb amputations. The primary patency rates were 92.2%, 76.8%, and 61.3% at 12, 24, and 36 months, respectively, while the primary-assisted patency rates were 94.4%, 83.2%, and 75.6% at 12, 24, and 36 months, respectively. Conclusion The combined CFA endarterectomy with SFA stenting plus Shuxuening Injection infusion appears to offer a safe, less invasive, and effective treatment option to patients with chronic lower extremity ischemia due to complex multifocal peripheral artery disease. |
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