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| Influence of Fuzheng Huayu Tablet (扶正化瘀片) on mental state and social function of patients with post-hepatitis B liver cirrhosis |
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| KeyWord:post-hepatitis B liver cirrhosis Fuzheng Huayu Tablet mental state social activity |
| Author Name | Affiliation | E-mail | | Xin Deng | Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College, Nanning, 530011, China | | | Jian Liang | Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College, Nanning, 530011, China | lj99669@163.com | | Fa-sheng Wu | Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College, Nanning, 530011, China | | | Yan-bo Li | Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College, Nanning, 530011, China | | | Ya-ping Zhang | Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College, Nanning, 530011, China | | | Yan-fang Tang | Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College, Nanning, 530011, China | |
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| Abstract: |
| Objective:To observe the influence of Fuzheng Huayu Tablet(扶正化瘀片,FZHYT)on mental state and social activity of patients with post-hepatitis B liver cirrhosis(LC-HB).Methods:Adopting grouped randomized double-blinded control method,180 LC-HB patients in 3 research centers were distributed to 2 groups,the treated group and the control group,90 in each group.Patients in the treated group were administered with FZHYT;while those in the control group treated with conventional therapy combined with placebo,the course for ail patients were 6 months.Their mental state and social activity were evaluated before treatment,after 3 months’ treatment and at terminal of the 6-month therapeutic course by estimating with Zung self-rating anxiety scale(SAS),self-rating depression scale(SDS)and social deficit screening scale(SDSS). Additionally,the basic demographic materials,liver function,cirrhosis index,hepatic and splenic images,blood coagulation function,etc.in the patients were tested and compared as well.Results:As compared with before treatment,the normal rate of SAS and SDS scores increased and the social deficit rate decreased in the treated group significantly after treatment,showing statistical significance(P<0.05 or P<0.01);while in the control group, change was only shown in the social deficit(P<0.01),inter-group comparisons after treatment showed significant differences in all the three indexes(P<0.05 or P<0.01).Additionally,after treatment,levels of liver function, cirrhosis,blood coagulation function and splenomegaly in the treated group were all improved significantly (P<0.05 or P<0.01),and the improvements were better than those in the control group(P<0.01)in levels of total bilirubin(TBIL),albumin(ALB),typeⅣcollagen(Ⅳ-C),prothrombin time(PT),prothrombin activity(PTA). Conclusion:Most patients of LC-HB have mental disturbance and social activity deficit,which could definitely be improved by intervention with Chinese FZHYT. |
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