|
| The Effect of Chaiqin Chengqi Decoction (柴芩承气汤) on Modulating Serum Matrix Metalloproteinase 9 in Patients with Severe Acute Pancreatitis |
| |
| View Full Text View/Add Comment Download reader |
|
| KeyWord:severe acute pancreatitis, systemic inflammatory response syndrome, matrix metalloproteinase-9, Chaiqin Chengqi Decoction |
|
| Hits: 1292 |
| Download times: 960 |
| Abstract: |
| Objective: To investigate the effect of Chaiqin Chengqi Decoction (柴芩承气汤, CQCQD) on regulating serum matrix metalloproteinase 9 (MMP-9) in patients with severe acute pancreatitis (SAP). Methods: Thirty-five SAP patients hospitalized in West China Hospital from September 1, 2008 to February 28, 2009 were randomly assigned to two groups using a computer-derived random number sequence in a ratio of 1:1, treatment group (18 patients) and the placebo control group (17 patients). The patients in the treatment group were administered with CQCQD by gastric perfusion (50 mL/2 h) and retention enema (200 mL/6 h) for 7 days. The two groups had similar baseline information. The clinical indicators, including the initial Balthazar's computed tomography (CT) score, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scores on 1st, 3rd, 5th and 7th day, incidences and durations of complications and the serum C-reactive protein (CRP), levels of MMP-9 on the 1st, 3rd, 5th and 7th day, were recorded and compared between the two groups. Results: The serum MMP-9, CRP and the APACHE Ⅱ scores on the 3rd, 5th and 7th day in the treatment group were lower than those in the control group (P<0.05). The serum MMP-9 was positively correlated with the APACHE Ⅱ score on the 1st day (r=0.430, P=0.01). The durations of acute respiratory distress syndrome (5.4±2.4 vs. 2.9±1.3), acute hepatitis (4.6±0.8 vs. 1.9±0.6) and acute heart failure (3.9±1.6 vs. 1.3±0.6, P<0.05) in the control group were longer than those in the treatment group. Conclusion: CQCQD could decrease the serum MMP-9 to relieve the severity of clinical symptoms and prevent the development of multiple organ dysfunction syndrome in patients with SAP. |
| Close |
|
|
|
