中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Buyang Huanwu Decoction (补阳还五汤) Reduces Infarct Volume and Enhances Estradiol and Estradiol Receptor Concentration in Ovariectomized Rats after Middle Cerebral Artery Occlusion

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KeyWord:Buyang Huanwu Decoction, focal cerebral ischemic, estrogen, estrogen receptor, Chinese medicine

Author Name	Affiliation	E-mail
LIU Bai-yan, SONG Xiao-ling, YI Jian
CAI Guang-xian	Key Laboratory of Internal Medicine, Hunan University of Traditional Chinese Medicine, Changsha (410007), China	lby1203@sina.com

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Abstract:

Objective: To investigate the effect of Buyang Huanwu Decoction (补阳还五汤, BYHWD) on estradiol (E2) and estradiol receptor (ER) in serum and brain in ovariectomized rats after middle cerebral artery occlusion (MCAO). Methods: Adult female rats were ovariectomized and focal cerebral ischemic was induced by MCAO. Rats were randomly divided into normal, ovariectomy (OVX), MCAO, OVX+MCAO, OVX+MCAO+E2, and OVX+MCAO+BYHWD group. Rats were administered BYHWD 5 g/kg daily, estradiol valerate 500 μg/kg per day or distilled water for 7 consecutive days. Neuronal function and infarct volume were measured on day 7 after artery occlusion, and E2 and ER concentration in serum and brain were checked by enzyme-linked immunosorbent assay. Results: BYHWD significantly improved the neurological behavior, reduced the infarction volume, increased E2 concentration in serum and brain, and increased ER concentration in the brain in ovariectomized rats after MCAO. Conclusion: The neuroprotective effects of BYHWD are associated with estrogen and its receptor.