中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
ZHU Ming-jun	1. Division of Cardiology and Central Laboratory, First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou (450000), China 2. Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China	zhumingjun317@163.com
WANG You-ping, XIE Shi-yang, LIU Wei-hong

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Abstract:

Objective: To evaluate the effects of Jiashen Prescription (加参方, JSP) on myocardial infarction (MI) size and cardiac function at the early stage of MI in rats. Methods: One hundred male Sprague-Dawley rats were subjected to sham-operation or MI induced by ligating the left anterior descending coronary artery. The rats with MI were treated with vehicle, JSP 3 and 6 g/(kg?d), or losartan 10 mg/(kg?d) for 1 week. Results: Compared with the vehicle-treated MI rats, 6 g/(kg?d) JSP reduced MI size 3 days after MI (P<0.05), and attenuated the MI-induced increases in left ventricular end-diastolic and end-systolic dimension and decreases in fractional shortening and ejection fraction 1 week after MI (P<0.05). In addition, 6 g/(kg?d) JSP and losartan were equally effective in reducing MI size and enhancing cardiac functional recovery. Conclusion: JSP reduces MI size and improves cardiac function after MI, suggesting that JSP has potential as a therapy for MI.