中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
LAI Fang, ZHANG Yan, XIE Dong-ping
HAN Yun	Intensive Care Unit, Fangcun Branch Hospital, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou (510145), China	hy660960@126.com

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Abstract:

Amlodipine is a dihydropyridine calcium channel blocker (CCB) that inhibits calcium influx into cardiac, vascular smooth muscle cells, and pancreatic beta cells, leading to dilation of arteries and arterioles and reduction in insulin secretion. Oral administration of amlodipine is absorbed slowly but almost completely, with a high oral bioavailability up to 60%–80%. It has a large volume of distribution (21 L/kg) and a long elimination phase (t1/2 35–48 h).(1-3) Severe amlodipine poisoning can lead to potential life-threatening complications such as profound hypotension, acute renal failure, noncardiogenic pulmonary edema, metabolic acidosis, and even cardiac arrest. As per the literature, in severe overdose cases of amlodipine, the taken doses ranged from 50 to 1,000 mg, with plasma concentrations of 67–393 ng/mL and a minimum lethal dose of 70 mg. However, there were cases where the overdose of amlodipine did not always lead to severe symptoms.(4-6) Clinical experience of amlodipine intoxication is limited. This report describes a severe case of overdose of amlodipine successfully treated by integrated Chinese and Western medicine.