中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Efficacy and Safety of Qiaoshao Formula (翘芍方) on Patients with Lifelong Premature Ejaculation of Gan (Liver) Depression and Shen (Kidney) Deficiency Syndrome: A Randomized Controlled Trial

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KeyWord:lifelong premature ejaculation, Qiaoshao Formula, Chinese medicine, dapoxetine, intra-vaginal ejaculation latency time, premature ejaculation diagnostic tool

Author Name	Affiliation	E-mail
GUO Jun, GAO Qing-he, YU Guo-jin
WANG Fu	Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China	fu311306@163.com

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Abstract:

Objective: To observe the efficacy and safety of Qiaoshao Formula (翘芍方, QSF) on patients with lifelong premature ejaculation (LPE) of Gan (Liver) depression and Shen (Kidney) deficiency syndrome. Methods: A total of 60 LPE patients were randomly divided into treatment (QSF) and control (dapoxetine) groups. The treatment group received QSF twice a day and the control group received dapoxetine 1 to 2 h prior to planned sexual intercourse for 4 weeks. The outcomes included intra-vaginal ejaculation latency time (IELT), premature ejaculation diagnostic tool (PEDT), clinical global impression of change (CGIC), scores of Chinese medicine symptoms (CMSS), sex life satisfaction (SLS) and adverse events (AEs). Results: In the treatment group, the median IELT was 3 min vs. 1.5 min before and after treatment (P<0.05). PEDT in the treatment group was reduced to 11.76±1.68 from 15.83±2.30 after treatment (P<0.05). Besides, patient's SLS was improved from 1.30±0.05 to 6.30±0.04 (P<0.05), and spouse's SLS was increased from 1.30±0.08 to 6.10±0.06 (P<0.05); CMSS was decrease from 14.86±3.02 to 9.62±2.87 (P<0.05). In addition, no significant AE was observed in both groups. Conclusion: QSF may be effective and safe on LPE patients with Gan depression and Shen deficiency syndrome.