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| Evaluation of the Potential Inhibitory Activity of A Combination of L. Acidophilus, L. Rhamnosus and L. Sporogenes on Helicobacter Pylori: A Randomized Double-Blind Placebo-Controlled Clinical Trial |
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| KeyWord:probiotics, Helicobacter pylori, urea breath test, randomized double-blind placebo-controlled trial |
| Author Name | Affiliation | E-mail | | Chien-Ying Lee, Hung-Che Shih, Min-Chien Yu | | | | Chun-Che Lin | 1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan (40201), China
2.Department of Medicine, Chung Shan Medical University, Taichung, Taiwan, China
3. Division of Hepatogastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan (40201), China | forest65@ms8.hinet.net |
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| Abstract: |
| Objective: To investigate whether three strains of probiotics, L. acidophilus, L. rhamnosus, and L. sporogenes, had significant inhibitive effects on Helicobacter pylori (H. pylori). Methods: This is a 4-week, randomly assigned, parallel-group, doubled-blind, and placebo-controlled study. Fifty patients with a positive H. pylori infection urea breath test (△UBT) result > 10% and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 1:1. These subjects took one capsule of probiotics or placebo twice daily. The primary measurement was the change in △UBT values. Results: The △UBT values during the 4-week treatment period and the 2-week follow-up period were not significantly different between the treatment group and the placebo group, indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count (%) was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group (P=0.044), and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group (P=0.024) at week 2 of the treatment period, both of which reached statistical significance. The monocyte count was 5.75±1.26 in the treatment group and 4.72±0.99 in the placebo group at the end of the follow-up period (P=0.003). Conclusions: There was no significant inhibitive effects of the three probiotic strains (L. acidophilus, L. rhamnosus, and L. sporogenes) on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori , the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori, especially in resistance cases. |
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