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| Effect of Zuogui Pill (左归丸) on Monoamine Neurotransmitters and Sex Hormones in Climacteric Rats with Panic Attack |
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| KeyWord:Zuogui Pill, climacteric, panic attack, monoamine neurotransmitter, sex hormone, Chinese medicine |
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| Abstract: |
| Objective: To explore the effects of Chinese medicine prescription Zuogui Pill (左归丸, ZGP) on monoamine neurotransmitters and sex hormones in climacteric rats with induced panic attacks. Methods: Forty-eight climacteric female rats were randomized into 6 groups with 8 rats in each group: the control group, the model group, the low-, medium- and high-dose ZGP groups and the alprazolam group. Rats in the low-, medium- and high-dose ZGP groups were administered 4.725, 9.45, or 18.9 g/kg ZGP by gastric perfusion, respectively. The alprazolam group was treated by gastric perfusion with 0.036 mg/kg alprazolam. The control and model groups were treated with distilled water. The animals were pretreated once daily for 8 consecutive weeks. The behaviors of rats in the open field test and the elevated T-maze (ETM) were observed after induced panic attack, and the levels of brain monoamine neurotransmitters and the plasma levels of sex hormones were measured. Results: Compared with the control group, the mean ETM escape time and the levels of 5-hydroxytryptamine (5-HT) and noradrenalin (NE) of the model group were significantly reduced (P<0.05), Compared with the model group, the mean ETM escape time and the 5-HT and NE levels of all the ZGP groups increased significantly (P<0.05 or P<0.01). However, no significant difference was observed in the levels of sex hormones between the groups. Conclusion: Pretreatment with ZGP in climacteric rats may improve the behavior of panic attack, which may be related to increased 5-HT and NE in the brain. |
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