中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
Ji-Hwan Eom, Se-Yun Cheon, Kyung-Sook Chung
Hyo-Jin An	Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si Gangwon-do (220-702), Republic of Korea	hjan@sj.ac.kr

Hits: 932

Download times: 0

Abstract:

Objective: To evaluate the efficacy of Bawu Decoction (八物汤, BWD, Palmul-tang in Korean) against benign prostatic hyperplasia (BPH). Methods: Twenty-four male Wistar rats were divided into 4 groups, with 6 rats in each group. The 4 study groups included sham-operated group (CON), BPH model group, finasteride-treated group, and BWD-treated group. All the groups except CON group received a subcutaneous injection of 10 mg/kg of testosterone, while CON group received saline. Finasteride at a dose of 5 mg/kg was administered to the finasteride-treated group for a period of 4 weeks. BWD group received BWD at a dose of 200 mg/kg for 4 weeks. The prostatic weight, prostate weight to body weight ratio, relative prostate weight ratio, serum testosterone and dihydrotestosterone (DHT) level, and histological analysis of prostatic tissue were analyzed. Results: Compared to BPH model group, BWD administration was associated with reductions in prostatic weight, prostate and relative prostate weight ratio weight to body weight ratio (P<0.05). The concentration of serum testosterone and DHT were higher in BPH group compared with CON group (P<0.05). Administration of finasteride and BWD suppressed the elevation of serum testosterone and DHT levels significantly (both P<0.05). In addition, BWD suppressed the growth of prostatic tissue (P<0.05). Conclusion: BWD has suppressant effects on development of BPH through inhibition of serum testosterone and DHT.