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Research Progress on Reversing Multidrug Resistance in Tumors by Using Chinese Medicine
  
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KeyWord:tumor, multidrug resistance, reversal agents, Chinese medicine
Author NameAffiliationE-mail
ZHAO Huan-dong, XIE Hong-juan, LI Jian   
CHEN Yu-xiang School of Pharmacy, Central South University, Changsha (410013), China Chenyx008@aliyun.com 
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Abstract:
      Multidrug resistance (MDR) is a major cause of cancer chemotherapy failure, and it is important to develop suitable reversal agents to overcome MDR. A majority of chemical reversal agents have acceptable reversal effects. However, the toxicity and adverse reactions associated with these agents restricts their clinical use. Chinese medicines (CMs) have lower toxicities and adverse reactions and are associated with multiple components, multiple targets and reduced toxicity. CMs have several advantages and could reverse MDR, decrease drug dosage, enhance patient compliance and increase efficacy. This review summarizes the current progress of CM reversal agents.
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