中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

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Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice

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KeyWord:Miscanthus sinensis var. purpurascens flower extract, hair growth, human hair dermal papilla cell, hepatocyte growth factor, transforming growth factor β1

Author Name	Affiliation	E-mail
Gi Hee Jeong, William A Boisvert, XI Mei-zhu
Bog-Hieu Lee	Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong (17546), Republic of Korea	lbheelb@cau.ac.kr

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Abstract:

Objective: To investigate the hair growth-promoting effect of Miscanthus sinensis var. purpurascens (MSP) flower extracton on in vitro and in vivo models. Methods: MSP flower extract was extracted in 99.9% methanol and applied to examine the proliferation of human dermal papilla cells (hDPCs) in vitro at the dose of 3.92–62.50 μg/mL and hair growth of C57BL/6 mice in vivo at the dose of 1000 μg/mL. The expression of transforming growth factor β1 (TGF-β1), hepatocyte growth factor (HGF), β-catenin, substance P was measured by relative quantitative realtime polymerase chain reaction. Histopathological and immunohistochemical analysis were performed. Results: MSP (7.81 μg/mL) down-regulated TGF-β1 and up-regulated HGF and β-catenin in hDPCs (P<0.01). MSP (1000 μg/mL)-treated mice showed the earlier transition of hair follicles from the telogen to the anagen phase. The number of mast cells was lower in the MSP-treated mice than in other groups (P<0.05 vs. NCS group). Substance P and TGF-β1 were expressed in hair follicles and skin of the MSP group lower than that in negative control. Stem cell factor in hair follicles was up-regulated in the MSP-treated mice (P<0.01). Conclusion: The MSP flower extract may have hair growth-promotion activities.