中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Author Name	Affiliation	E-mail
LIN Fan, CHEN Bin-ling, WANG Yi-zheng
GAO Dong	College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China	junsong86@sohu.com

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Abstract:

Objective: To compare the angiogenesis behaviors of vascular endothelial growth factor (VEGF) and Chinese medicine Xuefu Zhuyu Decoction (血府逐瘀汤, XZD) treatments. Methods: Human microvascular endothelial cells (HMEC-1) were treated with various concentrations of either XZD-containing serum (XZD-CS) or VEGF for 24, 48, and 72 h, respectively. Cell viability, proliferation, migration, adhesion, and in vitro tube formation assays were used to assess their angiogenic effects. Results: VEGF promoted all cellular phases involved in angiogenesis including cell viability, proliferation, migration, adhesion, and tube formation (P<0.05 or P<0.01). Unlike the continuous promotion effects of VEGF at the above stages, XZD inhibited cell viability and proliferation (P<0.05 or P<0.01) and only promoted tube formation in the early phase of angiogenesis (P<0.01). Conclusions: These two medications promote different angiogenesis behaviors, which might be an important reason for their distinct therapeutic profile in clinical usage.