中国结合医学杂志（英文版）Chinese Journal of Integrative Medicine

Home

Chinese Version

Online office

Journal Online

Forthcoming Articles

Current Issue

Next Issue

Earlier Issues

Download

Editorial Board [2019/7/26]

Instructions for Authors [2015/1/26]

Instructions to Contributors [2013/3/25]

Top

Top Downloaded
Top Cited

Links

alljournals

扫描微信二维码，获取更多信息

Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure

View Full Text View/Add Comment Download reader

KeyWord:metabonomics, heart failure, ultrafiltration, Chinese medicine

Author Name	Affiliation	E-mail
GUO Li-jun, CHEN Ke-ji, SUN Ming-qian
MA Xiao-chang	Cardiovascular Disease Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China	maxiaochang@x263.net

Hits: 347

Download times: 0

Abstract:

Objective: To reveal the underlying relationships between Chinese medicine (CM) syndromes and ultrafiltration (UF) in the treatment of heart failure based on a metabonomic approach. Methods: Seventeen acute decompensated heart failure (ADHF) patients were enrolled, and their CM syndromes before and after UF were collected. In addition, their venous plasma collected before and after UF was used for liquid chromatograph mass spectrometer-based metabonomic analysis. Both reversed phase liquid chromatography and hydrophilic interaction liquid chromatography were used to analyze the plasma samples. Partial least-squares to latent structure-discriminant analyses were used for data analysis. Results: An obvious difference was observed pre and post-treatment. A total of 17 potential biomarkers associating with alterd syndromes with UF including hypoxanthine, 1-methylhistidine, phytosphingosine, O-decanoyl-R-carnitine, etc. were screened out, showing a significant change after UF. The major adjusted metabolic pathways were purine metabolism, histidine metabolism, leucine and isoleucine metabolism, arginine and proline metabolism, carnitine shuttle, sphingolipid metabolism and phospholipid metabolism. Conclusions: Metabonomic approach is a useful tool to identify potential biomarkers of altered syndromes link to UF and could provide a theoretical basis for further research on the therapeutic mechanism of UF combined with CM.