Quick Search:       Advanced Search
Chinese Version 
Online office
Journal Online
Download
Top
Links

扫描微信二维码,获取更多信息
Effect of mexican tea herb and pilular adina herb on concrescence of gastric mucosa in experimental gastric ulcer rats
  
View Full Text  View/Add Comment  Download reader
KeyWord:gastric ulcer  epidermal growth factor  nitrogen monoxidum  epidermal growth factor receptor  index of ulcer  mexican tea herb  pilular adina herb
Author NameAffiliationE-mail
Ming-bo Cao Department of Digestive Medicine, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, 710004, China

Xinxiang Medical College, Henan Province, China 
 
Prof. Lei Dong Department of Digestive Medicine, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, 710004, China donglei4488@sina.com 
Xin-ming Chang Department of Digestive Medicine, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, 710004, China  
Bai-cang Zou Department of Digestive Medicine, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, 710004, China  
Bin Qin Department of Digestive Medicine, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, 710004, China  
Hits: 2370
Download times: 469
Abstract:
      Objective To study the effect and mechanism of mexican tea herb and pilular adina herb (abbreviated to MP) on concrescence of gastric mucosa in experimental gastric ulcer rats by observing the changes of epidermal growth factor (EGF), nitrogen monoxidum (NO) and expression of epidermal growth factor receptor (EGFR). Methods The rat ulcer model was established by 100% glacial acetic injection into the subserosa. The ulcer index (UI) was measured by sliding caliper. The levels of NO and EGF in tissue and serum were measured by the nitrate reductase method and enzyme-linked immunosorbent assay, respectively. The expression of EGFR in the mucosa around the ulcer was detected by the immunohistochemical assay and microimage analysis system. Results (1) Compared with the model group, UI of MP groups (10, 15 and 20 mg·kg−1·d−1) and ranitidine group was lower (P<0.05 or P<0.01), the levels of NO and EGF in the tissue and serum were higher (P<0.05), the thickness of regenerated mucous membrane increased, and the width loss of lamina muscularis mucosa decreased (all P<0.05). (2) The expression of EGFR is weakly positive in gastric mucosa cells in the normal group, mainly in the cytoplasm and cytomembrane. In the model group, the expression of EGFR was mainly in epithelial cells in cervical part and basilar part of gastric gland around the ulcer margin, and the number of cells with EGFR weakly positive expression was more than that in the normal group. Compared with that in the normal and model groups, the number of cells with EGFR positive in MP groups and ranitidine group increased (all P<0.05), with weakly positive expression. Conclusion MP can protect gastric mucosa, cure gastric ulcer, restrain the secretion of gastric acid, and boost multiplication, differentiation, migration and repair of the endothelial cell by promoting the secretion of NO and EGF, and increasing the expression of EGFR of gastric mucosa epithelial cells.
Close